British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.

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This page was last edited on 13 Novemberat During and after the war, nonmilitary uses for the heavy metal chelating action of BAL became apparent. In This Article Introduction. Lorincz of the University of Michigan has no relevant ati relationships to disclose. Views Read Edit View history.

Dimercaprol | drug |

British anti-Lewisite is used in arsenic, gold, and mercury soluble inorganic compounds poisoning. We welcome suggested improvements to any of our articles. Skeletal formula and ball and stick model of dimercaprol. Any text you add should be original, not copied from other sources.

C Risk not ruled out. Retrieved from ” https: In other projects Wikimedia Commons. Although treatment with dimercaprol will increase the excretion of cadmium, there is a concomitant increase in renal cadmium concentration, so that its use in case of cadmium toxicity is to be avoided. Archived PDF from the original on 23 April It is a potentially toxic drug, and its use may be accompanied by multiple side effects. British anti-Lewisite is occasionally used for both acute heavy metal intoxication and Wilson disease.


Improvements in synthesis resulted in the development of effective therapeutic ointments and solutions.

Help us improve this article! Copper sulfate Ipecacuanha Syrup of ipecac. Internet URLs are the best. Experimental observations revealed that dimercaprol may be an effective neuroprotective agent.


From Wikipedia, the free encyclopedia. It has been postulated that, because BAL is nonpolar, it may accelerate the removal of copper from within the brain compared to more modern agents Scheimberg and Sternlieb ; Walshe If you are a former subscriber or have registered before, please log in first and then click select a Service Plan or contact Subscriber Services.

It does, however, remove inorganic mercury from the kidneys; but is not useful in the treatment of alkylmercury or phenylmercury toxicity. Eagle and Magnuson found that 48 patients with severe or mild symptoms of arsenical encephalopathy were effectively treated with BAL Eagle and Magnuson By the end of World War IIdimercaprol had also been found useful as an antidote against poisoning by several metals and semimetals—including arsenicgoldleadand mercury—that act by combining with cellular sulfhydryl groups.

British anti-Lewisite

Dimercaprol has been found to form stable chelates in vivo with many other metals including inorganic mercuryantimonybismuthcadmiumchromiumcobaltgoldand nickel. Unfortunately, our editorial approach may not be able to accommodate all contributions. Originally released November 30, ; last updated April 23, ; expires April 23, Retrieved 22 April Thank you for your feedback.


By using this site, you agree to the Terms of Use and Privacy Policy. Dimercaprol is itself toxic, lewisitte a narrow therapeutic range and a tendency to concentrate arsenic in some organs. Learn More in these related Britannica articles: Dimercaprol is a copper chelating agent that has been approved by the FDA to treat Wilson’s disease.

Nevertheless, BAL may still have some therapeutic value in patients who do not respond well to more modern agents Scheinberg and Sternlieb Dimercaprolalso called British anti-lewisite BALdrug that was originally developed to combat the effects of the blister gas lewisitewhich was used in chemical warfare. Television TVthe electronic delivery of moving images and sound from a source to a receiver. InPorter found a 7-fold increase in copper excretion in 2 patients with Wilson disease and some hritish in neurologic signs after treatment with BAL Porter Contact our editors with your feedback.

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